DYSF polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DYSF polyclonal antibody (Cat # PAB30927) shows strong positivity in the glomeruli and moderate membranous staining in tubular cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human DYSF.
Immunogen
Recombinant protein corresponding to human DYSF.
Sequence
CHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DYSF polyclonal antibody (Cat # PAB30927) shows strong positivity in the glomeruli and moderate membranous staining in tubular cells. -
Gene Info — DYSF
Entrez GeneID
8291Protein Accession#
O75923Gene Name
DYSF
Gene Alias
FER1L1, FLJ00175, FLJ90168, LGMD2B
Gene Description
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
dysferlin|dystrophy-associated fer-1-like 1
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Interactome
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Disease
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