JAG1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human JAG1.
Immunogen
Recombinant protein corresponding to human JAG1.
Sequence
LRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYI
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with JAG1 polyclonal antibody (Cat # PAB30923) shows strong cytoplasmic positivity in renal tubules with a granular pattern. -
Gene Info — JAG1
Entrez GeneID
182Protein Accession#
P78504Gene Name
JAG1
Gene Alias
AGS, AHD, AWS, CD339, HJ1, JAGL1, MGC104644
Gene Description
jagged 1 (Alagille syndrome)
Gene Ontology
HyperlinkGene Summary
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq
Other Designations
OTTHUMP00000030278|jagged 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1.
Karamchandani DM, Lehman HL, Ohanessian SE, Massé J, Welsh PA, Odze RD, Goldblum JR, Berg AS, Stairs DB.
Diagnostic Pathology 2016 Feb; 11:23.
Application:IHC-P, Human, Human Barrett's esophagus.
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Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1.
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