SSR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SSR1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human SSR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of SSR1 (arrow) using SSR1 polyclonal antibody (Cat # PAB3091). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SSR1 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with SSR1 polyclonal antibody (Cat # PAB3091) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — SSR1
Entrez GeneID
6745Protein Accession#
NP_003135;P43307Gene Name
SSR1
Gene Alias
DKFZp781N23103, FLJ14232, FLJ22100, FLJ23034, FLJ78242, FLJ93042, TRAPA
Gene Description
signal sequence receptor, alpha
Omim ID
600868Gene Ontology
HyperlinkGene Summary
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq
Other Designations
SSR alpha subunit|TRAP alpha|translocon-associated protein alpha subunit
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Interactome
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Publication Reference
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Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation.
Hirama T, Miller CW, Koeffler HP.
FEBS Letters 1999 Jul; 455(3):223.
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The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges.
Hartmann E, Prehn S.
FEBS Letters 1994 Aug; 349(3):324.
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Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation.
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