BAD polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of RT-4 cell lysate with BAD polyclonal antibody (Cat # PAB30871).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with BAD polyclonal antibody (Cat # PAB30871) shows strong cytoplasmic positivity in cells of tubules.
Immunofluorescence
Immunofluorescent staining of A-431 cells with BAD polyclonal antibody (Cat # PAB30871) (Green) shows positivity in mitochondria.
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant human BAD.
Immunogen
Recombinant protein corresponding to human BAD.
Sequence
QEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMG
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of RT-4 cell lysate with BAD polyclonal antibody (Cat # PAB30871).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with BAD polyclonal antibody (Cat # PAB30871) shows strong cytoplasmic positivity in cells of tubules.Immunofluorescence
Immunofluorescent staining of A-431 cells with BAD polyclonal antibody (Cat # PAB30871) (Green) shows positivity in mitochondria. -
Gene Info — BAD
Entrez GeneID
572Protein Accession#
Q92934Gene Name
BAD
Gene Alias
BBC2, BCL2L8
Gene Description
BCL2-associated agonist of cell death
Omim ID
603167Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq
Other Designations
BCL-X/BCL-2 binding protein|BCL2-antagonist of cell death protein|BCL2-binding component 6|BCL2-binding protein
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Interactomes
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Pathways
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Diseases
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