Western blot analysis of FRAT1 (arrow) using rabbit FRAT1 polyclonal antibody (Cat # PAB3084). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FRAT1 gene (Lane 2) (Origene Technologies).
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq
GSK-3 binding protein FRAT1,OTTHUMP00000020201,OTTHUMP00000059391,proto-oncogene FRAT1