Pan Cytokeratin polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with Pan Cytokeratin polyclonal antibody (Cat # PAB30830).
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant human Pan Cytokeratin.
Immunogen
Recombinant protein corresponding to full length human Pan Cytokeratin.
Host
Rabbit
Theoretical MW (kDa)
40-67
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with Pan Cytokeratin polyclonal antibody (Cat # PAB30830).Immunofluorescence
Flow Cytometry
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Gene Info — KRT7
Entrez GeneID
3855Protein Accession#
P08729; Q04695; P05783; Q7Z794; Q01546Gene Name
KRT7
Gene Alias
CK7, K2C7, K7, MGC129731, MGC3625, SCL
Gene Description
keratin 7
Omim ID
148059Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
cytokeratin 7|keratin, 55K type II cytoskeletal|keratin, simple epithelial type I, K7|keratin, type II cytoskeletal 7|sarcolectin|type II mesothelial keratin K7
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Gene Info — KRT17
Entrez GeneID
3872Protein Accession#
P08729; Q04695; P05783; Q7Z794; Q01546Gene Name
KRT17
Gene Alias
K17, PC, PC2, PCHC1
Gene Description
keratin 17
Gene Ontology
HyperlinkGene Summary
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq
Other Designations
cytokeratin-17
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Gene Info — KRT18
Entrez GeneID
3875Protein Accession#
P08729; Q04695; P05783; Q7Z794; Q01546Gene Name
KRT18
Gene Alias
CYK18, K18
Gene Description
keratin 18
Gene Ontology
HyperlinkGene Summary
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
cell proliferation-inducing protein 46|cytokeratin 18
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Gene Info — KRT76
Entrez GeneID
51350Protein Accession#
P08729; Q04695; P05783; Q7Z794; Q01546Gene Name
KRT76
Gene Alias
HUMCYT2A, KRT2B, KRT2P
Gene Description
keratin 76
Gene Ontology
HyperlinkGene Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq
Other Designations
cytokeratin 2|keratin 2p
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Gene Info — KRT77
Entrez GeneID
374454Protein Accession#
P08729; Q04695; P05783; Q7Z794; Q01546Gene Name
KRT77
Gene Alias
K1B, KRT1B, MGC148087
Gene Description
keratin 77
Omim ID
611158Gene Ontology
HyperlinkGene Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13
Other Designations
keratin 1B
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Interactome
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Pathway
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Disease
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Publication Reference
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Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies.
J Woodcock-Mitchell, R Eichner, W G Nelson, T T Sun.
The Journal of Cell Biology 1982 Nov; 95(2 Pt 1):580.
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Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies.
S C Tseng, M J Jarvinen, W G Nelson, J W Huang, J Woodcock-Mitchell, T T Sun.
Cell 1982 Sep; 30(2):361.
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Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies.
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