TNFRSF8 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Hodgkin's lymphoma with TNFRSF8 polyclonal antibody (Cat # PAB30825).
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant human TNFRSF8.
Immunogen
Recombinant protein corresponding to full length human TNFRSF8.
Host
Rabbit
Theoretical MW (kDa)
105-120
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Hodgkin's lymphoma with TNFRSF8 polyclonal antibody (Cat # PAB30825).Immunofluorescence
Flow Cytometry
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Gene Info — TNFRSF8
Entrez GeneID
943Protein Accession#
P28908Gene Name
TNFRSF8
Gene Alias
CD30, D1S166E, KI-1
Gene Description
tumor necrosis factor receptor superfamily, member 8
Omim ID
153243Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD30 antigen|CD30L receptor|Ki-1 antigen|OTTHUMP00000001783|cytokine receptor CD30|lymphocyte activation antigen CD30
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Interactome
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Pathway
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Disease
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Publication Reference
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CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.
Smith, C.A. and Gruss, H.J. and Davis, T. and Anderson, D. and Farrah, T. and Baker, E. and Sutherland, G.R. and Brannan, C.I. and Copeland, N.G. and Jenkins, N.A. and Grabstein, K.H. and Gliniak, B. and McAlistar, I.B. and Fanslow, W. and Alderson, M. and Falk, B. and Gimpel, S. and Gillis, S. and Din, W.S. and Goodwin, R.G. and Armitage, R.J.
Cell 1993 Jul; 73(7):1349.
Application：Func, Human, CVl/EBNA, HDLM-2, Karpas 299, PBT cells.
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CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.
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