TP63 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human TP63.
Immunogen
Recombinant protein corresponding to human TP63.
Host
Rabbit
Theoretical MW (kDa)
63
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate cancer with TP63 polyclonal antibody (Cat # PAB30824).Immunofluorescence
Flow Cytometry
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Gene Info — TP63
Entrez GeneID
8626Protein Accession#
Q9H3D4Gene Name
TP63
Gene Alias
AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
Gene Description
tumor protein p63
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq
Other Designations
amplified in squamous cell carcinoma|chronic ulcerative stomatitis protein|keratinocyte transcription factor|transformation-related protein 63|tumor protein p53-competing protein|tumor protein p53-like|tumor protein p73-like
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Interactome
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Disease
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Publication Reference
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Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples.
Terry J, Leung S, Laskin J, Leslie KO, Gown AM, Ionescu DN.
The American Journal of Surgical Pathology 2010 Dec; 34(12):1805.
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p63 is a prostate basal cell marker and is required for prostate development.
Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, Montironi R, McKeon F, Loda M.
The American Journal of Pathology 2000 Dec; 157(6):1769.
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Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples.
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