CDH15 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of CDH15 (arrow) using rabbit CDH15 polyclonal antibody (Cat # PAB3082). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH15 gene (Lane 2) (Origene Technologies).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CDH15 polyclonal antibody (Cat # PAB3082) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH15.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDH15.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of CDH15 (arrow) using rabbit CDH15 polyclonal antibody (Cat # PAB3082). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH15 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CDH15 polyclonal antibody (Cat # PAB3082) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CDH15
Entrez GeneID
1013Protein Accession#
NP_004924;P55291Gene Name
CDH15
Gene Alias
CDH14, CDH3, CDHM, MCAD
Gene Description
cadherin 15, type 1, M-cadherin (myotubule)
Omim ID
114019Gene Ontology
HyperlinkGene Summary
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq
Other Designations
M-cadherin|cadherin 15|cadherin 15, M-cadherin (myotubule)|cadherin-14|cadherin-3|muscle-cadherin|myotubule-cadherin
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Interactome
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Pathway
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Disease
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Publication Reference
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Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.
Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS.
PNAS 2003 Apr; 100(7):3989.
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The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.
Hollnagel A, Grund C, Franke WW, Arnold HH.
Molecular and Cellular Biology 2002 Jul; 22(13):4760.
Application：IF, WB-Ti, Mouse, Muscle, Granule cells.
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Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
Meigs TE, Fields TA, McKee DD, Casey PJ.
PNAS 2001 Jan; 98(2):519.
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Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.
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