RYR2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human RYR2.
Immunogen
Recombinant protein corresponding to human RYR2.
Sequence
QDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with RYR2 polyclonal antibody (Cat # PAB30806) shows distinct cytoplasmic positivity in neuronal cells.Immunofluorescence
Immunofluorescent staining of A-431 cells with RYR2 polyclonal antibody (Cat # PAB30806) (Green) shows positivity in plasma membrane, cytoplasm and nucleus but excluded from the nucleoli. -
Gene Info — RYR2
Entrez GeneID
6262Protein Accession#
Q92736Gene Name
RYR2
Gene Alias
ARVC2, ARVD2, VTSIP
Gene Description
ryanodine receptor 2 (cardiac)
Gene Ontology
HyperlinkGene Summary
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq
Other Designations
cardiac muscle ryanodine receptor|cardiac muscle ryanodine receptor-calcium release channel
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Interactome
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