ALDH2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALDH2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human ALDH2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of ALDH2 (arrow) using rabbit ALDH2 polyclonal antibody (Cat # PAB3078). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALDH2 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with ALDH2 polyclonal antibody (Cat # PAB3078) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — ALDH2
Entrez GeneID
217Protein Accession#
NP_000681;P05091Gene Name
ALDH2
Gene Alias
ALDH-E2, ALDHI, ALDM, MGC1806
Gene Description
aldehyde dehydrogenase 2 family (mitochondrial)
Omim ID
100650Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq
Other Designations
ALDH class 2|acetaldehyde dehydrogenase 2|liver mitochondrial ALDH|mitochondrial aldehyde dehydrogenase 2|nucleus-encoded mitochondrial aldehyde dehydrogenase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach.
Chen L, Davey Smith G, Harbord RM, Lewis SJ.
PLoS Medicine 2008 Mar; 5(3):e52.
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Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z, Guo QH.
World Journal of Gastroenterology 2008 Mar; 14(9):1444.
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A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry.
Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM.
Inhalation Toxicology 2008 Feb; 20(4):375.
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Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach.
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