PTPN12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: RT-4 and Lane 2: U-251MG sp cell lysates with PTPN12 polyclonal antibody (Cat # PAB30775).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PTPN12 polyclonal antibody (Cat # PAB30775) shows strong cytoplasmic positivity in Purkinje cells.
Immunofluorescence
Immunofluorescent staining of U-251 MG with PTPN12 polyclonal antibody (Cat # PAB30775) (Green) shows positivity in plasma membrane and cytoplasm.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PTPN12.
Immunogen
Recombinant protein corresponding to human PTPN12.
Sequence
SVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAAT
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: RT-4 and Lane 2: U-251MG sp cell lysates with PTPN12 polyclonal antibody (Cat # PAB30775).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PTPN12 polyclonal antibody (Cat # PAB30775) shows strong cytoplasmic positivity in Purkinje cells.Immunofluorescence
Immunofluorescent staining of U-251 MG with PTPN12 polyclonal antibody (Cat # PAB30775) (Green) shows positivity in plasma membrane and cytoplasm. -
Gene Info — PTPN12
Entrez GeneID
5782Protein Accession#
Q05209Gene Name
PTPN12
Gene Alias
PTP-PEST, PTPG1
Gene Description
protein tyrosine phosphatase, non-receptor type 12
Omim ID
600079Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000025119|protein-tyrosine phosphatase G1|tyrosine-protein phosphatase non-receptor type 12
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Interactome
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Disease
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