Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunofluorescence

Entrez GeneID

Protein Accession#

Gene Name

TAF10

Gene Alias

TAF2A, TAF2H, TAFII30

Gene Description

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

Omim ID

Gene Ontology

Gene Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq

Other Designations

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kD|TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD|TBP-related factor 10|transcription initiation factor TFIID 30 kD subunit