Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with EPS8 polyclonal antibody (Cat # PAB30649) shows cytoplasmic positivity in exocrine glandular cells and islet cells.
Immunofluorescent staining of U-251 MG with EPS8 polyclonal antibody (Cat # PAB30649) (Green) shows positivity in the Golgi apparatus.
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq