Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with NR4A2 polyclonal antibody (Cat # PAB30608) shows moderate membranous and nuclear positivity in cells in tubules.
Immunofluorescent staining of SiHa cells with NR4A2 polyclonal antibody (Cat # PAB30608) (Green) shows positivity in nucleus but excluded from the nucleoli.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
NGFI-B/nur77 beta-type transcription factor homolog,T-cell nuclear receptor NOT,intermediate-early receptor protein,nur related protein-1, human homolog of,orphan nuclear receptor NURR1,transcriptionally inducible nuclear receptor related 1