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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with FGF3 polyclonal antibody (Cat # PAB30592) shows strong nuclear and cytoplasmic positivity in trophoblastic cells and moderate cytoplasmic positivity in decidual cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-2 OS with FGF3 polyclonal antibody (Cat # PAB30592) shows positivity in cytoplasm and nucleus but excluded from the nucleoli. Antibody staining is shown in green.

Entrez GeneID

2248

Protein Accession#

P11487

Gene Name

FGF3

Gene Alias

HBGF-3, INT2

Gene Description

fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)

Omim ID

164950 610706

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq

Other Designations

INT-2 proto-oncogene protein|V-INT2 murine mammary tumor virus integration site oncogene homolog|fibroblast growth factor 3|murine mammary tumor virus integration site 2, mouse|oncogene INT2