Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with TNIK polyclonal antibody (Cat # PAB30586) shows strong cytoplasmic positivity in glandular cells.
Immunofluorescent staining of human cell line U-2 OS with TNIK polyclonal antibody (Cat # PAB30586) shows positivity in cytoplasm and nucleus but excluded from the nucleoli. Antibody staining is shown in green.
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM