MACC1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with MACC1 polyclonal antibody (Cat # PAB30555) shows moderate cytoplasmic positivity in cells in tubules.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with MACC1 polyclonal antibody (Cat # PAB30555) shows positivity in mitochondria. Antibody staining is shown in green.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human MACC1.
Immunogen
Recombinant protein corresponding to human MACC1.
Sequence
PLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSF
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user. Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with MACC1 polyclonal antibody (Cat # PAB30555) shows moderate cytoplasmic positivity in cells in tubules.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with MACC1 polyclonal antibody (Cat # PAB30555) shows positivity in mitochondria. Antibody staining is shown in green. -
Gene Info — MACC1
Entrez GeneID
346389Protein Accession#
Q6ZN28Gene Name
MACC1
Gene Alias
7A5, SH3BP4L
Gene Description
metastasis associated in colon cancer 1
Gene Ontology
HyperlinkGene Summary
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM
Other Designations
putative binding protein 7a5
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