STAT2 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human urinary bladder with STAT2 polyclonal antibody (Cat # PAB30553) shows distinct cytoplasmic positivity in urothelial cells.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with STAT2 polyclonal antibody (Cat # PAB30553) shows positivity in plasma membrane and cytoplasma. Antibody staining is shown in green.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human STAT2.
Immunogen
Recombinant protein corresponding to human STAT2.
Sequence
DPTQLAEMIFNLLLEEKRILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user. Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human urinary bladder with STAT2 polyclonal antibody (Cat # PAB30553) shows distinct cytoplasmic positivity in urothelial cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with STAT2 polyclonal antibody (Cat # PAB30553) shows positivity in plasma membrane and cytoplasma. Antibody staining is shown in green. -
Gene Info — STAT2
Entrez GeneID
6773Protein Accession#
P52630Gene Name
STAT2
Gene Alias
ISGF-3, MGC59816, P113, STAT113
Gene Description
signal transducer and activator of transcription 2, 113kDa
Omim ID
600556Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq
Other Designations
interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2
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Interactome
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Pathway
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Disease
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