Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with MAPKAPK5 polyclonal antibody (Cat # PAB30537) shows strong nuclear positivity in glandular cells.
Immunofluorescent staining of human cell line U-251 MG with MAPKAPK5 polyclonal antibody (Cat # PAB30537) shows positivity in cytoplasm and nucleus but excluded from the nucleoli. Antibody staining is shown in green.
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq