Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with TRAF7 polyclonal antibody (Cat # PAB30536) shows strong cytoplasmic and membranous positivity in glandular cells.
Immunofluorescent staining of human cell line U-2 OS with TRAF7 polyclonal antibody (Cat # PAB30536) shows positivity in plasma membrane and vesicles. Antibody staining is shown in green.
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM