Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bronchus with TANK polyclonal antibody (Cat # PAB30534) shows cytoplasmic and membranous positivity in respiratory epithelial cells.
Immunofluorescent staining of human cell line Hep G2 with TANK polyclonal antibody (Cat # PAB30534) shows positivity in cytoplasm. Antibody staining is shown in green.
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
TRAF family member-associated NF-KAPPA-B activator,TRAF interacting protein TANK