SETDB1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon using SETDB1 polyclonal antibody (Cat # PAB30521) shows strong nuclear, cytoplasmic and membranous positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of A-431 cells using SETDB1 polyclonal antibody (Cat # PAB30521) shows positivity in plasma membrane, cytoplasm and nucleus (green) but excluded from the nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human SETDB1.
Immunogen
Recombinant protein corresponding to amino acids 290 - 437 of human SETDB1.
Sequence
KLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQD
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1 - 4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200 - 1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon using SETDB1 polyclonal antibody (Cat # PAB30521) shows strong nuclear, cytoplasmic and membranous positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of A-431 cells using SETDB1 polyclonal antibody (Cat # PAB30521) shows positivity in plasma membrane, cytoplasm and nucleus (green) but excluded from the nucleoli. -
Gene Info — SETDB1
Entrez GeneID
9869Protein Accession#
Q15047Gene Name
SETDB1
Gene Alias
ESET, KG1T, KIAA0067, KMT1E
Gene Description
SET domain, bifurcated 1
Omim ID
604396Gene Ontology
HyperlinkGene Summary
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described
Other Designations
ERG-associated protein with a SET domain, ESET
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Interactome
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Pathway
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Disease
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