Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon using SETDB1 polyclonal antibody (Cat # PAB30521) shows strong nuclear, cytoplasmic and membranous positivity in glandular cells.
Immunofluorescent staining of A-431 cells using SETDB1 polyclonal antibody (Cat # PAB30521) shows positivity in plasma membrane, cytoplasm and nucleus (green) but excluded from the nucleoli.
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described