DUSP10 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney using DUSP10 polyclonal antibody (Cat # PAB30515) shows strong cytoplasmic positivity with granular pattern in renal tubules.
Immunofluorescence
Immunofluorescent staining of A-431 cells using DUSP10 polyclonal antibody (Cat # PAB30515) shows positivity in nucleus (green) but excluded from the nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human DUSP10.
Immunogen
Recombinant protein corresponding to amino acids 180 - 291 of human DUSP10.
Sequence
FMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1 - 4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20 - 1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney using DUSP10 polyclonal antibody (Cat # PAB30515) shows strong cytoplasmic positivity with granular pattern in renal tubules.Immunofluorescence
Immunofluorescent staining of A-431 cells using DUSP10 polyclonal antibody (Cat # PAB30515) shows positivity in nucleus (green) but excluded from the nucleoli. -
Gene Info — DUSP10
Entrez GeneID
11221Protein Accession#
Q9Y6W6Gene Name
DUSP10
Gene Alias
MKP-5, MKP5
Gene Description
dual specificity phosphatase 10
Omim ID
608867Gene Ontology
HyperlinkGene Summary
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000035380|dual specificity phosphatase MKP-5|map kinase phosphatase 5|serine/threonine specific protein phosphatase
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Interactome
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Disease
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