Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human urinary bladder with EMR3 polyclonal antibody (Cat # PAB30504) shows dot like cytoplasmic positivity in urothelial cells at 1:50-1:200 dilution.
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. [provided by RefSeq