Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with GAP43 polyclonal antibody (Cat # PAB30502) shows strong nuclear positivity in neuronal and glial cells at 1:200-1:500 dilution.
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
axonal membrane protein GAP-43,calmodulin-binding protein P-57,nerve growth-related peptide GAP43,neural phosphoprotein B-50,neuromodulin,neuron growth-associated protein 43,protein F1