Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with GDF10 polyclonal antibody (Cat # PAB30500) shows strong cytoplasmic positivity in cells of seminiferous ducts at 1:20-1:50 dilution.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq