Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with NOX4 polyclonal antibody (Cat # PAB30497) shows strong cytoplasmic positivity in cells in tubules at 1:50-1:200 dilution.
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants