Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human urinary bladder with SLITRK6 polyclonal antibody (Cat # PAB30485) shows moderate cytoplasmic and membranous positivity in urothelial cells at 1:50-1:200 dilution.
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM
4832410J21Rik,OTTHUMP00000066012,slit and trk like 6,slit and trk like gene 6