CCR6 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with CCR6 polyclonal antibody (Cat # PAB30484) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center at 1:50-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human CCR6.
Immunogen
Recombinant protein corresponding to human CCR6.
Sequence
KYNTQGSDVCEPKYQTVSEPIRWKLLML
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with CCR6 polyclonal antibody (Cat # PAB30484) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center at 1:50-1:200 dilution. -
Gene Info — CCR6
Entrez GeneID
1235Protein Accession#
P51684Gene Name
CCR6
Gene Alias
BN-1, CD196, CKR-L3, CKR6, CKRL3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, GPRCY4, STRL22
Gene Description
chemokine (C-C motif) receptor 6
Omim ID
601835Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq
Other Designations
G protein-coupled receptor 29|OTTHUMP00000017618|OTTHUMP00000017619|chemokine (C-C) receptor 6|chemokine receptor-like 3|seven-transmembrane receptor, lymphocyte, 22
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Interactome
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Pathway
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Disease
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