Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with OS9 polyclonal antibody (Cat # PAB30471) shows strong positivity in spermatogenic cells at 1:200-1:500 dilution.
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq