Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DRD1 polyclonal antibody (Cat # PAB30467) shows strong cytoplasmic positivity in epidermal cells at 1:50-1:200 dilution.
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq