Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with ATP7B polyclonal antibody (Cat # PAB30464) shows strong cytoplasmic positivity in glandular cells at 1:20-1:50 dilution.
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq