Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with CLDN11 polyclonal antibody (Cat # PAB30462) shows strong membranous positivity in cells in seminiferous ducts at 1:50-1:200 dilution.
The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. [provided by RefSeq