Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DSC1 polyclonal antibody (Cat # PAB30460) shows strong membranous positivity in epidermal cells at 1:200-1:500 dilution.
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq