Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with GPLD1 polyclonal antibody (Cat # PAB30455) shows strong cytoplasmic positivity in cells of tubules at 1:20-1:50 dilution.
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq