Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with KRT10 polyclonal antibody (Cat # PAB30449) shows moderate cytoplasmic positivity in keratinocytes at 1:200-1:500 dilution.
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq