Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with CDCP1 polyclonal antibody (Cat # PAB30440) shows moderate cytoplasmic positivity in glandular cells and extracellular material of glandular lumina at 1:20-1:50 dilution.
The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
CUB domain-containing protein 1,OTTHUMP00000164120,transmembrane and associated with src kinases