FGFR3 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of FGFR3 polyclonal antibody (Cat # PAB3043) in Jurkat cell lysate. FGFR3 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGFR3 polyclonal antibody (Cat # PAB3043) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FGFR3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human FGFR3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of FGFR3 polyclonal antibody (Cat # PAB3043) in Jurkat cell lysate. FGFR3 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGFR3 polyclonal antibody (Cat # PAB3043) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — FGFR3
Entrez GeneID
2261Protein Accession#
P22607Gene Name
FGFR3
Gene Alias
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Description
fibroblast growth factor receptor 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000149959|achondroplasia, thanatophoric dwarfism|hydroxyaryl-protein kinase|tyrosine kinase JTK4
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Targeting FGFR pathway in human hepatocellular carcinoma (HCC) expressing pFGFR and pMET for anti-tumor activity.
Jo JC, Choi EK, Shin JS, Moon JH, Hong SW, Lee HR, Kim SM, Jung SA, Lee DH, Jung SH, Lee SH, Kim JE, Kim KP, Hong YS, Suh YA, Jang SJ, Choi EK, Lee JS, Jin DH, Kim TW.
Molecular Cancer Therapeutics 2015 Nov; 14(11):2613.
Application：IP, WB, Human, Human liver carcinoma cells.
-
FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells.
Sturla LM, Merrick AE, Burchill SA.
British Journal of Cancer 2003 Oct; 89(7):1276.
Application：IP, WB, Human, TC-32 cells.
-
[Typical features of craniofacial growth of the FGFR3-associated coronal synostosis syndrome (so-called Muenke craniosynostosis)].
Reinhart E, Eulert S, Bill J, Wurzler K, Phan The L, Reuther J.
Mund-, Kiefer- und Gesichtschirurgie : MKG 2003 Apr; 7(3):132.
-
The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum.
Lievens PM, Liboi E.
The Journal of Biological Chemistry 2003 May; 278(19):17344.
-
Targeting FGFR pathway in human hepatocellular carcinoma (HCC) expressing pFGFR and pMET for anti-tumor activity.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com