Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with PTH1R polyclonal antibody (Cat # PAB30417) shows moderate positivity in a subset of tubules at 1:50-1:200 dilution.
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. [provided by RefSeq
PTH/PTHr receptor,PTH/PTHrP type I receptor,parathyroid hormone receptor 1,parathyroid hormone/parathyroid hormone-related peptide receptor,parathyroid hormone/parathyroid hormone-related protein receptor,seven transmembrane helix receptor