MBTPS2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human MBTPS2.
Immunogen
Recombinant protein corresponding to human MBTPS2.
Sequence
EVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum with MBTPS2 polyclonal antibody (Cat # PAB30392) shows moderate cytoplasmic positivity in glandular cells at 1:20-1:50 dilution. -
Gene Info — MBTPS2
Entrez GeneID
51360Protein Accession#
O43462Gene Name
MBTPS2
Gene Alias
FLJ32174, S2P
Gene Description
membrane-bound transcription factor peptidase, site 2
Omim ID
300294Gene Ontology
HyperlinkGene Summary
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response
Other Designations
OTTHUMP00000023046|membrane-bound transcription factor protease, site 2
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