Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human thyroid with PTPN22 polyclonal antibody (Cat # PAB30385) shows strong cytoplasmic positivity in glandular cells at 1:20-1:50 dilution.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
OTTHUMP00000013720,lymphoid-specific protein tyrosine phosphatase,protein tyrosine phosphatase, non-receptor type 8