ERBB4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERBB4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ERBB4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ERBB4 polyclonal antibody (Cat # PAB3038) in HL-60 cell lysate. ERBB4 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with ERBB4 polyclonal antibody (Cat # PAB3038) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — ERBB4
Entrez GeneID
2066Protein Accession#
Q15303Gene Name
ERBB4
Gene Alias
HER4, MGC138404, p180erbB4
Gene Description
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Omim ID
600543Gene Ontology
HyperlinkGene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4|v-erb-a erythroblastic leukemia v
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Interactome
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Pathway
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Disease
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Publication Reference
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ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab.
Ellegård S, Veenstra C, Pérez-Tenorio G, Fagerström V, Gårsjö J, Gert K, Sundquist M, Malmström A, Wingren S, Elander NO, Hallbeck AL, Stål O.
Oncology Letters 2019 Mar; 17(3):3371.
Application:IHC-P, Human, Human breast cancer.
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Aberrant accumulation of ErbB4 in progressive supranuclear palsy.
Murakami A, Nakamura M, Kaneko S, Lin WL, Dickson DW, Kusaka H.
Neuropathology and Applied Neurobiology 2018 Jan; [Epub].
Application:IEM, IF, IHC-P, Human, Brains from patients with progressive supranuclear palsy.
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Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment.
Cheng QC, Tikhomirov O, Zhou W, Carpenter G.
The Journal of Biological Chemistry 2003 Oct; 278(40):38421.
Application:IP, WB, Human, T47D, T47-14 cells.
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WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.
Komuro A, Nagai M, Navin NE, Sudol M.
The Journal of Biological Chemistry 2003 Aug; 278(35):33334.
Application:IF, Monkey, COS-7 cells.
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A constitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines.
Williams EE, Trout LJ, Gallo RM, Pitfield SE, Bryant I, Penington DJ, Riese DJ 2nd.
Cancer Letters 2003 Mar; 192(1):67.
Application:IP, WB-Tr, Mouse, Mouse C127 fibroblasts.
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ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab.
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