Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast with TSPAN6 polyclonal antibody (Cat # PAB30366) shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq
A15 homolog,OTTHUMP00000023652,tetraspan TM4SF,tetraspanin TM4-D,transmembrane 4 superfamily member 6