Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with SOX6 polyclonal antibody (Cat # PAB30361) shows strong nuclear positivity in a subset of cells in seminiferous ducts (mature spermatids) at 1:1000-1:2500 dilution.
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants