Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver with ARG1 polyclonal antibody (Cat # PAB30348) shows strong cytoplasmic and nuclear positivity in hepatocytes at 1:2500-1:5000 dilution.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. [provided by RefSeq