Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with CTSH polyclonal antibody (Cat # PAB30344) shows strong cytoplasmic positivity, with a granular pattern, in cells in tubules at 1:200-1:500 dilution.
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
N-benzoylarginine-beta-naphthylamide hydrolase,aleurain,cathepsin B3,cathepsin BA