Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with LTBP2 polyclonal antibody (Cat # PAB30338) shows strong cytoplasmic positivity in a granular pattern in glandular cells at 1:500-1:1000 dilution.
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq