Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bone marrow with T polyclonal antibody (Cat # PAB30336) shows moderate nuclear positivity in a subset of bone marrow poietic cells at 1:20-1:50 dilution.
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq
OTTHUMP00000017588,T brachyury homolog,T brachyury-like,transcription factor T