Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with USP11 polyclonal antibody (Cat # PAB30334) shows distinct nuclear and cytoplasmic positivity of basal cells in seminiferous ducts at 1:50-1:200 dilution.
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq